Plumbago zeylanica and its anti-inflammatory properties in arthritis: a molecular analysis
Researchers identified that bioactive compounds from the root of Plumbago zeylanica may act on multiple inflammatory pathways related to rheumatoid arthritis (RA). Using a network pharmacology and molecular docking approach, the study revealed significant interactions between phytocompounds such as lumbagic acid and zeylenone with important targets, including mTOR and AKT1. These compounds demonstrated promising binding affinities, suggesting that P. zeylanica may modulate inflammatory and signaling processes associated with RA. Although the results are promising, experimental validation in in vitro and in vivo studies is necessary to confirm these mechanisms and support future therapeutic development. This work provides a systematic biological basis for understanding the multi-target anti-arthritic potential of P. zeylanica.
