Summary
Researchers have demonstrated that the methanolic extract of Ziziphus abyssinica (ZAE) exhibits significant antidiabetic effects in streptozotocin-induced diabetic mice. In a study with control and treatment groups, the dose of 600 mg/kg of ZAE reduced blood glucose levels by 66%, normalizing them compared to the diabetic group. Additionally, there was recovery of body weight and improvements in lipid profiles, with increased HDL and reduced LDL. Hepatic and renal markers also normalized, and histopathology revealed preservation of pancreatic β cells. These results not only highlight the efficacy of ZAE in glycemic control but also its ability to protect multiple organs, suggesting a therapeutic potential that aligns with the traditional use of the plant.
Key points
- Ziziphus abyssinica (ZAE) reduced glucose by 66% in diabetic mice at 600 mg/kg.
- Significant improvements in lipid profiles: HDL increased to 61.8 mg/dL and LDL dropped to 37.5 mg/dL.
- Preservation of pancreatic β cells was observed, indicating pancreatic protection.
- Normalization of hepatic markers (ALT, AST, ALP) and renal markers (creatinine, urea).
- The study suggests that ZAE may offer glycemic control and protection in multiple organs, where glibenclamide failed.
✦ For you
If you are seeking natural alternatives for blood sugar control, consider including Ziziphus abyssinica in your diet, whether as a tea or supplement. Observe how your body reacts and keep a diary of glucose levels. If you have diabetes or persistent symptoms, it is essential to consult a qualified healthcare professional.
For practitionersExpand
In clinical practice, the inclusion of Ziziphus abyssinica (ZAE) may be considered as an alternative or complement to conventional diabetes treatment. Evaluate patients' response to the extract, especially regarding glycemic control and hepatic and renal health. The dose of 600 mg/kg proved effective, but adjust according to patient individuality and monitor side effects.