Vitex trifolia and its analgesic and anti-inflammatory properties: development of a herbal cream

Summary

Researchers have demonstrated that the ethanolic extract of Vitex trifolia can reduce inflammation by up to 71.5% in edema models in rats. Using pain tests induced by acetic acid and edema models, the study evaluated the efficacy of the extract compared to standard medications. The developed herbal cream, containing 0.4% of Vitex trifolia, showed favorable physical characteristics and stability for 90 days, especially at 30°C. Although the extract showed significant anti-inflammatory potential, the analgesic activity was not statistically relevant compared to the control group. Phytochemical analysis revealed stable retention of compounds such as phenolics and flavonoids during storage. These findings highlight the relevance of Vitex trifolia in traditional medicine and its applicability in topical formulations.

Key points

Vitex trifolia reduced EPP-induced edema by up to 71.5% in 120 minutes (p < 0.001).
The extract did not show significant analgesic activity in pain tests compared to control (p > 0.05).
The herbal cream maintained stable physical characteristics (pH: 4.26-4.99; viscosity: 8683-40.065 cP) over 90 days.
Phytochemical analysis showed stable retention of phenolics, flavonoids, and proanthocyanidins during storage.
The anti-inflammatory efficacy was comparable to standard medications in experimental models.

✦ For you

If you suffer from muscle pain or skin inflammations, consider observing how your body reacts to creams containing plant extracts, such as Vitex trifolia. Pay attention to any relief or worsening of symptoms after application. It is always important to consult a qualified healthcare professional if symptoms persist.

For practitionersExpand

When considering the use of Vitex trifolia in topical formulations, assess the stability of the product and the presence of active compounds. The observed anti-inflammatory efficacy may be useful in protocols for inflammatory conditions, but the lack of significant analgesic activity should be taken into account when formulating recommendations for patients.