Summary
Researchers evaluated shilajit, an organic-mineral resin, in a study that investigated its antioxidant activity and acute toxicity. The results showed that shilajit has a moderate capacity to scavenge free radicals, with IC50 values ranging from 1.657 to 3.502 mg/mL for ABTS and from 2.042 to 6.011 mg/mL for DPPH. Samples rich in urolithin A and phenolic acids demonstrated a significant increase in total and free testosterone levels, with increases of approximately 2.5 times and 3.5 times, respectively, compared to the control group. During the 14-day period, no clinical signs of toxicity or significant changes in food and water consumption were observed, suggesting low acute toxicity (LD50 > 2000 mg/kg). However, mild to moderate degenerative changes were identified in hepatic and renal tissues, indicating the need for further studies to assess the long-term safety of standardized shilajit.
Key points
- Shilajit demonstrated moderate capacity to scavenge free radicals, with IC50 between 1.657 and 3.502 mg/mL.
- Increase of 2.5 times in total testosterone and 3.5 times in free testosterone in specific samples.
- No mortality or clinical signs of toxicity were observed during 14 days of observation.
- Mild to moderate degenerative changes were found in hepatic and renal tissues.
- Need for more studies to assess the long-term safety of shilajit.
✦ For you
If you are looking for natural ways to support your testosterone levels, consider observing how you feel after introducing shilajit into your routine. Pay attention to changes in energy, mood, and overall well-being. It is always important to consult a qualified healthcare professional before starting any supplement, especially if you have pre-existing health conditions.
For practitionersExpand
When considering the use of shilajit (Asphaltum) in your formulations, note the potential effects on testosterone levels and hepatic and renal health. Assess the patient's condition and adjust doses as necessary, taking into account individual response and possible side effects. Long-term safety still needs to be investigated.