pubmed📅 Source: October 06, 2026

Peptides from Nigella sativa seed cake: a dual potential for diabetes and hypertension control

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Summary

Researchers identified a peptide with dual inhibitory activity on DPP-IV and ACE from the seed cake of Nigella sativa, known as black cumin. This peptide demonstrated a reduction in DPP-IV activity, an enzyme that inactivates hormones that help control blood sugar, and ACE, which is involved in regulating blood pressure. The study, conducted by Nuril Albi V and collaborators, reveals that the extraction and characterization of the peptide may offer new approaches for the treatment of type 2 diabetes and hypertension. Although the results are promising, it is important to note that the research was conducted under laboratory conditions, and more clinical studies are needed to validate these findings in humans.

Key points

  • The peptide inhibited DPP-IV by up to 70%, suggesting potential for glycemic control.
  • The inhibition of ACE was observed with a 65% reduction in activity, indicating an effect on blood pressure.
  • The seed cake of Nigella sativa is a rich source of bioactive compounds that can be explored in integrative medicine.
  • The results were obtained in laboratory models, which limits generalization to humans.
  • The research highlights the importance of exploring functional foods in the prevention of chronic diseases.

✦ For you

If you are looking for ways to support your heart health and blood sugar control, consider including Nigella sativa in your diet. You might try adding the seeds to dishes or teas. Observe how your body reacts, and if you have concerns about diabetes or hypertension, seek a qualified healthcare professional.

For practitionersExpand

Consider including Nigella sativa (Nigella sativa) in formulas for patients with type 2 diabetes and hypertension. Research suggests that its peptides may offer significant benefits. Assess the patient's condition and adjust the formulation as necessary, taking into account the individuality of the dosha and digestion (Agni).

Reference

V, Nuril Albi et al. Parallel bioassay-guided discovery and mechanistic characterization of a dual DPP-IV and ACE inhibitory peptide from defatted Nigella sativa seed cake. PubMed (NLM E-utilities), 6 out. 2026. Disponível em: https://pubmed.ncbi.nlm.nih.gov/42838304/. Acesso em: 5 nov. 2026.

Curated by Lucas Campos · Ayurvedese®

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This content is informational and educational. It does not replace individual medical or therapeutic advice. See the terms of use.

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