openalex📅 Source: September 01, 20262 reads

Functional changes in the human brain in anxiety disorders: a review

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Summary

Researchers have identified significant functional changes in the brains of individuals with anxiety disorders. The review by Anuradha Gunvant Gawande highlights how specific brain regions, such as the amygdala and the prefrontal cortex, exhibit hyperactivity and hypoactivity, respectively. These changes are associated with symptoms such as excessive fear and difficulty regulating emotions. The review also suggests that dysregulation of the HPA axis—the communication between the brain and the glands that control stress—may be a central factor in anxiety disorders. Although the findings are promising, most reviewed studies use small samples, which limits the generalizability of the results. The connection between these modern findings and Ayurvedic concepts of emotional imbalance and agni (digestion) may offer new perspectives for the integrative treatment of these disorders.

Key points

  • The amygdala shows hyperactivity in response to fear stimuli in anxiety disorders.
  • The prefrontal cortex exhibits hypoactivity, making emotional regulation difficult.
  • HPA axis dysregulation is associated with anxiety symptoms.
  • Most reviewed studies have small samples, limiting the generalizability of the findings.
  • The relationship between brain changes and emotional symptoms can be explored through Ayurveda.

✦ For you

If you feel anxiety, observe how your emotions affect your body. Try practicing deep breathing techniques to help calm the mind and body. Pay attention to how your digestion may be affected during stressful times. If symptoms persist, seek a qualified healthcare professional.

For practitionersExpand

Consider evaluating the relationship between anxiety symptoms and patients' brain function. Stress management techniques, such as breathing practices and meditation, can be integrated into treatment. Assessing the patient's agni and digestion may offer additional insights into their emotional and physical state.

Reference

GAWANDE, Anuradha Gunvant Gawande*Anuradha Gunvant. FUNCTIONAL CHANGES IN HUMAN BRAIN IN ANXIETY DISORDERS: A REVIEW. OpenAlex, 1 set. 2026. Disponível em: https://doi.org/10.5281/zenodo.22160631. Acesso em: 17 out. 2026.

Curated by Lucas Campos · Ayurvedese®

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This content is informational and educational. It does not replace individual medical or therapeutic advice. See the terms of use.

Functional changes in the human brain in anxiety disorders: a review · Ayurvedese® Feed