Summary
Researchers analyzed the interaction between leaf extracts of Moringa oleifera and Hygrophila auriculata, revealing that the combination of these plants exhibits significant antibacterial and antibiofilm potential against Proteus mirabilis. The extracts were prepared by different methods, including Ayurvedic decoction and steam extraction. Results showed that the combined treatment reduced the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) to 0.1220–0.4883 mg/mL and 0.2441–0.9766 mg/mL, respectively, compared to individual treatments. Furthermore, embryonic toxicity in zebrafish was lower with the combination, presenting an LC50 value of 1812.74 µg/mL. FTIR analysis indicated the presence of important functional groups, suggesting that these extracts have potential for developing alternative therapies, especially in urinary tract infections, where P. mirabilis is a causative agent, in a scenario of increasing antibiotic resistance.
Key points
- The combination of Moringa oleifera and Hygrophila auriculata showed reduced MIC of 0.1220–0.4883 mg/mL against P. mirabilis.
- The combined treatment showed lower embryonic toxicity in zebrafish, with an LC50 of 1812.74 µg/mL.
- The extracts were prepared by methods such as Ayurvedic decoction and steam extraction, showing superior efficacy compared to individual treatments.
- FTIR analysis revealed the presence of functional groups such as hydroxyl and carbonyl, indicating therapeutic potential.
- The study suggests that these extracts may be a viable alternative for managing urinary tract infections.
✦ For you
Consider including Moringa oleifera and Hygrophila auriculata in your diet, whether as teas or in dishes, to enhance your health. Observe how your body reacts to these herbs and whether you notice any improvement in your energy or well-being. If you have persistent symptoms, seek a qualified healthcare professional.
For practitionersExpand
Evaluate the inclusion of Moringa oleifera (Moringa) and Hygrophila auriculata (Kulekhara) in formulations for patients with urinary tract infections, especially in cases of antibiotic resistance. The combination may offer a synergistic effect, reducing toxicity and increasing efficacy. Consider adjusting the dosage based on patient response and the preparation method of the extracts.