Summary
Researchers identified 15 priority metabolites in Baliospermum montanum root extract, including triterpenoids such as cucurbitacin C and ursolic acid, which are associated with gastrointestinal effects. Using an integrative approach that combines untargeted metabolomics and computational pharmacology, the study revealed that oral administration of the extract in Wistar rats resulted in significant changes in fecal characteristics and defecation frequency, especially at the dose of 900 mg/kg. No significant changes were observed in body weight or signs of liver damage, indicating the safety of the extract. Histopathological analysis of the colon showed changes in the morphology of goblet cells and in the architecture of the mucosa, suggesting an impact on intestinal secretory activity. These findings highlight the relevance of B. montanum extract for gastrointestinal health and pave the way for future investigations on the identified metabolites.
Key points
- Cucurbitacin C demonstrated a favorable interaction profile with the dopamine D2 receptor (DRD2), a gastrointestinal regulatory target.
- Oral administration of the extract in rats resulted in a significant increase in defecation frequency and fecal characteristics at doses of 300 to 900 mg/kg.
- There was no evidence of liver damage, with biochemical parameters such as AST, ALT, and ALP remaining stable.
- Histopathological changes in the colon indicated alterations in intestinal secretory activity and mucosal architecture.
- The metabolites were classified as putative annotations of level 2, as reference patterns were not analyzed under identical experimental conditions.
✦ For you
If you are interested in improving your gastrointestinal health, consider observing how your body reacts to different foods and herbs. Gradual introduction of plant extracts, such as Baliospermum montanum, may be an option, but always pay attention to any changes in your well-being. If you experience persistent discomfort, seek a qualified healthcare professional.
For practitionersExpand
In clinical practice, consider including Baliospermum montanum in protocols for patients with gastrointestinal disorders. Assess patient responses to different dosages and monitor fecal characteristics and defecation frequency. The safety of the extract, with no evidence of liver damage, is a positive point for its use.