Summary
Researchers reviewed 14 studies on the plant Centella asiatica and its triterpenoids, such as asiaticoside and asiatic acid, in relation to depression. Most studies, which included 13 preclinical experiments and one human study, showed promising results for antidepressant effects. The identified mechanisms involve BDNF/CREB-related signaling, monoaminergic regulation, reduction of neuroinflammation and oxidative stress, as well as modulation of the hypothalamic-pituitary-adrenal axis. Despite favorable preclinical evidence, the research is still heterogeneous and clinical efficacy in humans is not established. The authors suggest that future studies should focus on standardized preparations and rigorous clinical trials.
Key points
- Most of the reviewed studies (13 out of 14) showed positive antidepressant effects of Centella asiatica.
- The main mechanisms include modulation of the hypothalamic-pituitary-adrenal axis and regulation of BDNF/CREB, which are crucial for neuroplasticity.
- Current evidence is predominantly derived from animal models, with only one human study included.
- The triterpenoids asiaticoside and asiatic acid were the most studied regarding their effects on depression.
- The research highlights the need for rigorous clinical trials to validate efficacy in humans.
✦ For you
If you have been feeling sad or unmotivated, consider incorporating practices that promote mental well-being into your routine, such as regular physical exercise and relaxation techniques. Centella asiatica is a plant that has shown potential in studies, but it is important to remember that each organism reacts differently. If symptoms persist, seek a qualified health professional.
For practitionersExpand
When considering Centella asiatica (Centella asiatica) in your formulations, observe the potential effects on depression and anxiety, especially in patients showing signs of chronic stress. Modulation of the HPA axis and promotion of neuroplasticity may be relevant in the therapeutic approach. Assess the need for additional studies to substantiate clinical efficacy and safety of use in humans.