Summary
Researchers have demonstrated that the extract from the stem bark of Cenostigma pyramidale, popularly known as 'catingueira', exhibits significant spasmolytic and antidiarrheal effects. In experiments conducted with isolated guinea pig ileum, the trichloromethane fraction of the extract showed concentration-dependent spasmolytic activity, with a logEC50 of 1.690 ± 0.09625 µg/mL. In mice, doses of 250 and 500 mg/kg of the stem bark extract reduced total fecal mass, while leaf and bark extracts decreased intestinal transit at doses of 250, 500, and 750 mg/kg. Additionally, 750 mg/kg of the leaf extract was effective in reducing intestinal fluid accumulation. The observed antidiarrheal effects may be related to inhibition of smooth muscle contraction, possibly due to the presence of compounds such as tannins and flavonoids in the extracts, which are known for their beneficial properties in traditional medicine.
Key points
- The trichloromethane fraction of the stem bark extract showed spasmolytic activity with a logEC50 of 1.690 ± 0.09625 µg/mL.
- Leaf and stem bark extracts reduced intestinal transit at doses of 250, 500, and 750 mg/kg.
- Doses of 250 and 500 mg/kg of the stem bark extract decreased total fecal mass in mice.
- The antidiarrheal effect may be attributed to inhibition of smooth muscle, possibly due to tannins and flavonoids.
- The study was conducted in experimental models, which limits the generalization of results to humans.
✦ For you
If you experience episodes of diarrhea, consider observing your diet and the presence of stress, which can influence intestinal health. Try to include foods rich in tannins, such as black tea and some fruits, which may help regulate intestinal transit. If symptoms persist, seek a qualified healthcare professional.
For practitionersExpand
In clinical practice, consider the use of Cenostigma pyramidale extracts as part of a protocol for diarrhea control, especially in cases where inhibition of smooth muscle contraction is desired. Assess the presence of imbalanced doshas and adjust the formulation as needed, taking into account patient individuality.