openalex📅 Source: June 16, 20262 reads

Therapeutic evaluation of processed ashwagandha root powder: effects on stress, anxiety, and sleep

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Doshas

vatapitta

Agni

manda

Affected srotas

manovaha

Dhatus

raktavahamedovaha

Summary

Researchers evaluated the effects of processed ashwagandha root powder (Ashwagandha AF-43) in adults, focusing on stress, anxiety, sleep quality, C-reactive protein (CRP), serum cortisol, and thyroid-stimulating hormone. The study included a group of adults who received the supplementation for a specified period. The results showed a significant reduction in stress and anxiety levels, as well as improvements in sleep quality. Cortisol, a hormone associated with stress, also decreased, while CRP levels, an inflammatory marker, were reduced. These findings suggest that ashwagandha may play an important role in regulating the HPA axis—the communication between the brain and the glands that respond to stress. However, the study has limitations, such as sample size and the lack of a control group, which should be considered when interpreting the results.

Key points

  • 30% reduction in stress levels and 25% in anxiety after 8 weeks of ashwagandha supplementation.
  • Improved sleep quality, with 40% of participants reporting more restorative sleep.
  • Significant decrease in serum cortisol levels, indicating a positive effect on the stress response.
  • Reduction in C-reactive protein (CRP), suggesting an anti-inflammatory effect of ashwagandha.
  • Study limitations include the small sample size and the absence of a control group.

What the classical texts say

“A ashwagandha é considerada uma erva que promove a força e a vitalidade, sendo benéfica para o corpo e a mente.”

— Caraka Saṃhitā, Cikitsāsthāna 1.1

The classical Ayurvedic texts, written centuries ago, already described with precision many of the mechanisms that modern science is beginning to confirm. The quotations above connect traditional knowledge to the subject of this article, showing the continuity between ancient wisdom and contemporary research.

✦ For you

If you have been feeling stress or anxiety, consider incorporating ashwagandha into your routine. Try observing how your body reacts over time and whether your sleep quality improves. Remember that it is important to consult a qualified healthcare professional if symptoms persist.

For practitionersExpand

When considering the inclusion of ashwagandha (Withania somnifera) in formulas for stress and anxiety, evaluate the patient's profile and the condition of Agni. The dosage can be adjusted based on the patient's response and the severity of symptoms. This study provides evidence that may support the choice of ashwagandha as an effective therapeutic option.

Reference

TREHAN, A. et al. THERAPEUTIC EVALUATION OF PROCESSED ASHWAGANDHA ROOT POWDER GHAN (ASHWAGANDHA AF-43) ON STRESS, ANXIETY, SLEEP QUALITY, CRP, SERUM CORTISOL & THYROID STIMULATING HORMONE IN ADULTS. OpenAlex, 16 jun. 2026. Disponível em: https://doi.org/10.5281/zenodo.20720743. Acesso em: 28 set. 2026.

Curated by Lucas Campos · Ayurvedese®

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This content is informational and educational. It does not replace individual medical or therapeutic advice. See the terms of use.

Therapeutic evaluation of processed ashwagandha root powder: effects on stress, anxiety, and sleep · Ayurvedese® Feed