Summary
Researchers identified 44 compounds from Ficus religiosa that may help alleviate delayed onset muscle soreness (DOMS), a common condition after physical exercise. Using network pharmacology and molecular simulations, the study revealed that inflammation, oxidative stress, and immune regulation are the main mechanisms of action. The study highlighted prostaglandin-endoperoxide synthase 2 (PTGS2) as a critical target, with compounds such as α-eudesmol and α-cadinol showing binding affinities superior to ibuprofen. Dynamic simulation showed that α-cadinol had the most stable binding, suggesting its potential as a therapeutic agent for managing DOMS. The authors, Kartika IGAA and colleagues, conclude that F. religiosa may be a viable alternative for treating this condition, with promising anti-inflammatory and analgesic effects.
Key points
- 44 compounds from Ficus religiosa were identified as potential for treating DOMS.
- PTGS2 is a critical target for the anti-inflammatory action of F. religiosa compounds.
- Compounds such as α-cadinol showed binding affinity superior to ibuprofen.
- Dynamic simulation revealed that α-cadinol presents stable binding due to robust hydrogen bonds.
- Mechanisms of action include inflammation, oxidative stress, and immune regulation.
✦ For you
If you exercise and experience delayed onset muscle soreness, consider including anti-inflammatory foods in your diet, such as turmeric and ginger, which may help relieve pain. Additionally, observe how your body reacts to different types of physical activity and adjust your routine as needed. If pain persists, seek a qualified healthcare professional.
For practitionersExpand
In clinical practice, consider including Ficus religiosa (Ashvattha) in protocols for patients presenting with delayed onset muscle soreness. Evaluate the combination with other anti-inflammatory herbal medicines and adjust the formulation according to the patient's response. Research suggests that compounds such as α-cadinol may be effective, so pay attention to their properties when formulating treatments.